Drug Delivery

Drug Delivery

SELECTION OF A DRUG DELIVERY SYSTEMS STARTS WITH A FOCUS ON A PRODUCT NOT A TECHNOLOGY

CMC Pharma uses proven approaches to develop long acting drug product formulations. We are specialists with extensive experience in formulation and analytical development of competing technologies that are appropriate for drug compounds with varying characteristics. CMC Pharma selects the best approaches to evaluate in vitro and in vivo.

cmc drug delivery selection

CMC uses select materials to stabilize drugs and prolong duration of delivery in classic parenteral formulations.

Biodegradable Polymers:

Biodegradable polymers are well known in drug delivery, particularly in microspheres. CMC Pharma uses these materials as an additive to our stable drug-organic vehicle formulations. The polymer gels upon injection and drug release is prolonged by diffusion from the in situ gel followed by polymer degradation. We have experience in vehicle and polymer selection to tailor release kinetics from days to months

Water-Soluble Polymers:

For aqueous formulations prolonged release can be accomplished by the addition of an appropriate polymer. Often these are relatively high viscosity but undergo significant shear thinning and can be injected with standard syringes and needs to accomplish delivery from days to weeks.

Hydrophobic additives:

We use our stable organic vehicle formulations and add very hydrophobic low molecular weight materials to obtain delivery from days to weeks.

Non-degradable polymers :

CMC Pharma scientists also have experience with fabricating and testing non-degradable polymeric implants for controlled release applications.

Injectable oils :

We can match drug properties to appropriate hydrophobic injection vehicles for a widely accepted long acting injectable approach.

Excipients:

CMC Pharma utilizes, when possible, excipients in the FDA inactive ingredient database that are found in commercial, FDA-approved products and are widely accepted in the pharma and biotech industries. These include excipients to solubilize (complexing agents, surfactants, solvents, etc.), stabilize (antioxidants, buffers etc.), or provide a formulation or drug delivery function (polymers, lipids, carriers, binders & disintegrants, etc.)